Repository Universitas Harapan Bangsa.
Digital collection of academic papers, undergraduate thesis, research

Repository Universitas Harapan Bangsa.
Digital collection of academic papers, undergraduate thesis, research


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TONIC EFFECTS TEST PEGAGAN (Centella asiatica L) SYRUPS ON WHITE MALE MICE

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Pengarang
Sunarti, S.Farm., M.Sc., Apt. - Personal Name
Yane Dila Keswara, M.Sc., Apt - Personal Name
Nur Aini Dewi Purnamasari, M.Sc., Apt - Personal Name
Pernyataan Tanggungjawab
Lampiran Berkas
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Bahasa
English
Penerbit
Ikatan Apoteker Indonesia
Tahun Terbit
2016
Tempat Terbit
Jakarta
Deskripsi Fisik

Abstract

Tonic Effects Test of Pegagan (Centella asiatica L.)
Syrups on White Male Mice
Pharmacy Faculty,
Universitas Setia Budi,
Surakarta
Sunarti1
, Yane Dila Keswara2
, Nuraini Dewi Purnamasari3
ABSTRACT: Centella asiatica L., or known as pegagan leaf, empirically can be
used as a tonic for organs such as liver, kidneys and brain. It also can increase
memory. In our society, Centella asiatica L., hasn’t been optimally processed as a
tonic. Commonly, it is processed by boiling or grating the leaf. Raw consumption
of this leaf inflicts bad taste. The aim of this research is to find out tonic effect
and determine the effective dose of herbal syrup Centella asiatica L . The effect
of tonic can be determined using natatory exhaustion method, by observing
stimulant effect of a certain drug to an animal.
Methods : This research used male mice were divided into 5 groups of treatment.
The first group: negative control without herbal syrup Centella asiatica L.,
substance, positive control 50 mg/kg body weight, first dose group 120 mg/kg
mice’s body weight, second dose group 150 mg/kg mice’s body weight and third
dose group 180 mg/kg mice’s body weight. The effect of tonic was observed
through the increasing duration of the mice’s self-defense ability when it was
swum.
Result: This research resulted that the use of herbal syrup Centella asiatica L.,
gave tonic effect on dose 120 mg/kg mice’s body weight, 150 mg/kg mice’s body
weight, and 180 mg/kg mice’s body weight. The most effective dose of the use
of herbal syrup Centella asiatica L., is on dose 180 mg/kg mice’s body weight.
Keyword : Syrup, Tonic, Centella asiatica L

ABSTRAK: Pegagan (Centella asiatica L.)secara empiris dapat digunakan
sebagai tonik untuk organ seperti hati, ginjal dan otak, dapat meningkatkan
memori. Pada masyarakat Centella asiatica L., belum diproses secara optimal
sebagai tonik. Umumnya, hanya dengan merebus atau mengiris daun. Konsumsi daun yang mentah menimbulkan rasa tidak enak. Tujuan dari penelitian ini adalah untuk mengetahui efek tonik dan menentukan dosis efektif
sirup herbal Centella asiatica L., Efek tonik dapat ditentukan dengan menggunakan metode kelelahan natatory, dengan mengamati efek stimulan obat
tertentu pada hewan. Penelitian ini menggunakan mencit jantan yang dibagi
menjadi 5 kelompok perlakuan. Kelompok ke-1: kontrol negatif tanpa sirup
herbal, zat Centella asiatica L., kontrol positif 50 mg / kg berat badan, kelompok dosis pertama 120 mg / kg berat badan mencit, kelompok dosis kedua
150 mg / kg berat badan mencit, kelompok dosis ketiga 180 mg / kg berat
badan mencit. Efek tonik diamati melalui peningkatan durasi kemampuan
pertahanan diri mencit ketika kelelahan. Penelitian ini menghasilkan bahwa
penggunaan sirup herbal Centella asiatica L., memberikan efek tonik pada
dosis 120 mg / kg berat badan mencit, 150 mg / kg berat badan mencit, dan
180 mg/kg berat badan mencit. Dosis yang paling efektif penggunaan sirup
herbal Centella asiatica L., pada dosis 180 mg / kg berat badan mencit.
Kata kunci : Sirup, Tonic, Centella asiatica L.


URL : https://repository.uhb.ac.id/index.php?p=show_detail&id=2531
APA Citation
Sunarti, S.Farm., M.Sc., Apt.. (2016). TONIC EFFECTS TEST PEGAGAN (Centella asiatica L) SYRUPS ON WHITE MALE MICE. (Digital collection of academic papers, undergraduate thesis & research). Retrieved from https://repository.shb.ac.id




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